Extended Data Fig. 4: Variability in dopamine responses across syllables.
From: Natural behaviour is learned through dopamine-mediated reinforcement
a, Syllable-averaged dopamine responses (reproduced from Fig. 2e, see Methods) across development (day 61−100) with the closest 10% relative distance (top) and furthest 10% relative distance (bottom) plotted above average ΔF/F signals (blue, closer renditions; red, further renditions; shading, ±s.e.m) sorted from weakest to strongest dopamine response. b, Example spectrograms for the three syllables with the strongest dopamine response (top) from early in development (day ≤ 76) and during adulthood (day > 90) (top) and the three syllables with the weakest dopamine response (bottom). Number indicates ranking (1, weakest; 25, strongest). c, Average over all syllables (n = 25) of the mean distance from all renditions on a given day to the adult (age > 90 days) median (grey shading, ±s.e.m.). d, Correlation between magnitude of dopamine response and syllable duration (black dots, 25 syllables; black line, best fit; n.s. P > 0.05, no significant correlation, Pearson linear correlation coefficient). e–g, Plotted as in d but for average s.d. per day of distance to adult version across development (e), per hour change in distance averaged across each day (f) and mean change in distance per day across development (g).
