Extended Data Fig. 7: Ca2+ block of GluA2-containing AMPARs at two binding sites. | Nature

Extended Data Fig. 7: Ca2+ block of GluA2-containing AMPARs at two binding sites.

From: GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels

Extended Data Fig. 7: Ca2+ block of GluA2-containing AMPARs at two binding sites.The alternative text for this image may have been generated using AI.

Fits of two binding site isotherm to Ca2+ inhibition data recorded at −100 mV of AMPARs composed of a. GluA1/A2 (n = 7), b. GluA1/A2-γ2 (n = 16), c. GluA1+CNIH−3/A2-γ2 (n = 9) and d. GluA1/A2-γ2 R607E (n = 8). The solid line corresponds to the sum of the two binding site isotherm and the dotted lines are the individual isotherm fits.

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