Extended Data Fig. 4: CIM-834 binds directly to SARS-CoV-2 M protein.
From: A coronavirus assembly inhibitor that targets the viral membrane protein
a, Offline affinity selection mass spectrometry (AS-MS) of 5 µM M protein with 5 µM CIM-834 (blue) or buffer control (purple), (mean ± s.d., n = 3 independent experiments). b, Example of extracted ion chromatogram (EIC) for CIM-834 with 10 ppm mass tolerance with M protein (blue) and buffer control (purple). c, MS spectrum corresponding to the EIC peak for CIM-834 with M protein (blue).
