Extended Data Fig. 3: Antibody titres for each of the measured vaccine antigens at 7 months of life subdivided by antibiotic exposure group.
From: Bifidobacteria support optimal infant vaccine responses
(a-f) IgG titres in sera at 7 months against 6 of the 13 capsular pneumococcal polysaccharides (PPS1, 6B, 9 V, 18 C, 19 F and 23 F) in the PCV13 vaccine that were significantly lower in Neo-ABX infants. (g-h) IgG titres against PPS4 and PPS5, which trended lower in Neo-ABX infants at 7 months. (i-m) IgG titres against other capsular pneumococcal polysaccharides that were not lower in Neo-ABX infants at 7 months. (n-t) IgG titres against (n) DT, (o) Hib-PRP, (p) TT, (q) PT, (r) HB sAG, (s) PRN and (t) FHA in sera collected from infants at 7 months. (u) anti-rotavirus vaccine IgA titres in sera collected from infants at 7 months. (a-u) No-ABX (n = 64 infants), Neo-ABX (n = 27 infants), IP-ABX (n = 43 infants), PN-ABX (n = 26 infants). Data in a-u are represented as boxplots with the box denoting the 25th and 75th percentiles, the whiskers the 5th and 95th percentiles, the middle bar is the median. Statistical significance was assessed in a-u using a generalised linear model (Gaussian distribution) adjusting for sex and baseline antibody titres. *unadjusted P < 0.05, ** P < 0.01. Exact P values are provided in the Source Data File. All P values are two-sided.
