Extended Data Fig. 4: Antibody titres for each of the measured antigens at 15 months of life subdivided by antibiotic exposure group.
From: Bifidobacteria support optimal infant vaccine responses
(a-u) IgG titres in sera at 15 months against (a) PPS14, (b) PPS19A, (c) Hib-PRP, (d) PPS6A, (e) PPS9V, (f) PPS19F, (g) PPS23F (all significantly lower in Neo-ABX and/or PN-ABX infants), (h) PPS1, (i) PPS3, (j) PPS4, (k) PPS5, (l) PPS6B, (m) PPS7F, (n) PPS18C, (o) DT, (p) TT, (q) PT, (r) HB sAG, (s) PRN, (t) FHA. (u) anti-rotavirus vaccine IgA titres in sera collected from infants at 15 months. a-u No-ABX (n = 65 infants), Neo-ABX (n = 26 infants), IP-ABX (n = 42 infants), PN-ABX (n = 27 infants). Data in a-u are represented as boxplots with the box denoting the 25th and 75th percentiles, the whiskers the 5th and 95th percentiles, the middle bar is the median. Statistical significance was assessed in a-u using a generalised linear model adjusting for sex and baseline antibody titres. * unadjusted P < 0.05, **P < 0.01. Exact P values are provided in the Source Data File. All P values are two-sided.
