Fig. 4: Integrated view of MET-types including modalities from Patch-seq and EM.
From: Connectomics of predicted Sst transcriptomic types in mouse visual cortex
a, First column, average percentage of synapses onto each postsynaptic target group. Second column, schematic summarizing the connectivity motifs observed from EM data. Third column, example cells from the EM dataset. Fourth column, average action potential (AP) traces per MET-type. Fifth column, transcriptomic cell types that comprise previously defined MET-types. b, This integrated view of MET-types now allows us to generate hypotheses such as the role of highly expressed genes in a given transcriptomic type on connectivity patterns. c, Dot plot showing the fraction of cells within the MET-type (circle size) and expression level (red to blue scale bar) of the genes that are differentially expressed across the transcriptomic types in MET-8, 4 and 6 (n = 18, 15 and 18, respectively) and present in at least 50% of one MET-type. Genes listed are the top five upregulated or downregulated genes by pairwise comparison (minus duplicates). aData previously published16. Credits: plots in a reproduced with permission from ref. 16, Cell Press.
