Extended Data Fig. 14: Postsynaptic neurons with a common input are more similar to each other than expected by a pairwise like-to-like rule at both axonal and synaptic scale.

a, Mean pre-post signal correlations in the data (dark gray, “observed”) and the model (blue, “expected”) are not significantly different, indicating that the model reproduces the expected pairwise like-to-like rule b, Mean pairwise in silico signal correlation of postsyns, reproduced from Fig. 5c. The observed data shows significantly higher postsyn to postsyn similarity than predicted by the model fit with only a pairwise rule, for three out of four projection types. c, As in a, but at “Axonal” scale. d, As in b, but at “Axonal” scale. e, As in c, but at “Synaptic” scale. f, As in d, but at “Synaptic” scale. For statistics and sample sizes, see Supplementary Tables 21, 22.