Extended Data Fig. 7: Goal-associated inhibitory decreases emerge during the first day of navigation of a novel environment.
a, Percent change of normalized residual firing rate from baseline for NS interneurons (blue) and pyramidal cells (red) that had a significant change in firing around the RZ as a function of time to RZ over three days of navigation of the first novel environment. (NS interneurons; Day 1, n = 9 cells, no significant effect of time; Day 2, n = 20 cells, P < 2.2e-16, main effect of time; Day 3, n = 20 cells, P = 3.6e-08, main effect of time; LMM. Pyramidal cells; Day 1, n = 184 cells, P = 0.0005, main effect of time; Day 2, n = 175 cells, P = 2.5e-10, main effect of time; Day 3, n = 199 cells, P < 2.2e-16, main effect of time; LMM). b, Raw firing rates of putative PV interneurons as a function of distance to the novel RZ during the first (light turquoise) and last block of 25 trials (dark turquoise) on the first day of navigation in the first novel environment. c, Cell-averaged bin counts with a significant PV firing reduction (n = 10, 6, 3, 3 cells for trial blocks 1-4). d, Field stability (left) and spatial information (right) for all pyramidal cells (n = 138 cells) on the first day of navigation in the first novel environment were not significantly different from early (lightest red) to late (darkest red) blocks of 25 trials. Data in a-c represent mean ± SEM.
