Extended Data Fig. 9: Structural comparison between structures of MPC and SemiSWEETs.
From: Structures and mechanism of the human mitochondrial pyruvate carrier
a, Structural comparison between the IMS-open MPC and an inward-open (cytoplasm-facing) SemiSWEET (PDB ID: 4X5M). b, Structural comparison between occluded structure of MPC and structures of SemiSWEETs (PDB IDs: 4RNG and 4QNC) in occluded conformation. c, Structural comparison between the matrix-facing MPC and an outward-open SemiSWEET (PDB ID: 4QND). d, The putative substrate-binding pocket in SemiSWEET. An occluded structure of SemiSWEET (PDB ID: 4RNG) was used for the cut-away surface generation. e, Comparison between the putative substrate-binding-pocket-forming residues in occluded structures of MPC and SemiSWEET.
