Extended Data Fig. 4: Structural features of MPC structures in the IMS-open state.
From: Structures and mechanism of the human mitochondrial pyruvate carrier
a, Overall structures of MPC purified in different conditions that exhibit IMS-open conformation. b, Structural alignment of the three MPC structures in IMS-open state. c, Superimposition of TMDs of MPC1 and MPC2. d, Structural details of MPC2-APH. e, Density of the cardiolipin molecule found between MPC2-APH and MPC1-TMD. f, Density of the PC molecule found between MPC1-TM1 and MPC2-TM2. All figures of local densities were generated by isomesh function in PyMOL at sigma value of 4.5.
