Extended Data Fig. 5: Prediction #3: Interareal connectivity preregistered analysis.
a, iEEG electrode coverage used to assess content-selective synchrony for IIT ROIs (top, Npatients = 4) & GNWT ROIs (bottom, Npatients = 21). Electrode coverage varied between ROIs as interareal connectivity was assessed between electrodes on a per-participant basis. In addition, two example category-selective electrodes are shown (right): one face-selective, and one object-selective. Error bars depict standard error of the mean. b, iEEG Pairwise phase consistency (PPC) analysis of task-irrelevant trials reveals significant content-selective synchrony (e.g. faces > objects for face-selective electrodes; left; objects > faces for object-selective electrodes; right) in V1/V2 ROIs (top row), but not in PFC ROIs (bottom row). Color bars represent the average change in PPC (face and object trials) for each node (face-selective, object-selective). Positive values reflect stronger connectivity for faces, while negative values reflect stronger connectivity for objects. c, MEG (N = 65) cortical time-series were extracted per participant from cortical parcels in V1/V2 (blue), PFC (green) and in a fusiform (red) ROIs. Category-selective signals were obtained by creating a category-selective GED filter (i.e., contrasting face-object trials against any other stimulus category trials) on the activity extracted from the fusiform ROI. Face- (bottom left) and object-selective (bottom right) responses averaged across participants are shown at the bottom. Error bars depict 95% CI. Here and below, significance was assessed using cluster-based permutation tests, p < 0.05, two-sided. d, MEG PPC analysis of task-irrelevant trials (N = 65) reveals significant category-selective synchrony below 25 Hz for the face-selective GED filter (i.e., faces > objects for face-selective electrodes) in both V1/V2 (top row) and PFC ROIs (bottom row) and for the object-selective synchrony (objects > faces for object-selective electrodes) in the PFC ROI only. Brain surfaces in panels a,c are from Freesurfer.
