Extended Data Fig. 8: Supplemental information regarding colonization resistance experiments.
From: Diet outperforms microbial transplant to drive microbiome recovery in mice
N values for all panels are presented in Table S10A. St CFU counts from female (A) and male (B) cohorts through t = 96 hpi. (C) Log10 transformed Infection AUC for all infected treatment groups. (D) Body weight after infection as a percentage of pre-infection body weight for all treatment groups. (E) St CFU counts across body tissue sites for all infected treatment groups at t = 96 hpi. (F) Cecal and (G) colonic histopathology scoring of all treatment groups at t = 96 hpi broken down by subscore. (H-P) mRNA expression of immune genes in cecal mucosal scrapings at t = 96 hpi based on RT-qPCR. Expression is normalized to the housekeeping gene Actb and the RC-PBS-PBS treatment group. See Table S10 for statistics and additional information. In (A), (B), (D), and (F), data are presented as mean ± SD. For boxplots in (C), (E), and (G - O), the middle line is the median, the upper and lower hinges reflect the first and third quartiles, and the whiskers extend to 1.5*IQR. Data beyond the whiskers are plotted as outlying points.
