Fig. 1: Diverse SNr neuronal responses during the forelimb task.
From: Dynamic basal ganglia output signals license and suppress forelimb movements
a, Schematic and ethogram of forelimb movements executed in the food-pellet-reaching assay: reach, grasp, retract and handle. b, The probability density of the relative timing of task events across single mice (thin lines) and on average (thick lines) (left); and the average hand velocity (black line) across all of the recorded mice (n = 17, grey lines) aligned to reach start (middle) and retract start (right). c, The location of recorded SNr single units (n = 646) with a baseline firing rate of greater than 5 Hz in an anteroposterior projection of the SNr aligned to Allen CCF space. Top is dorsal and right is lateral. d, Single-trial raster plots (top; trials are sorted by reach duration) and the perievent mean ± s.e.m. firing rate (bottom) of two SNr single units aligned to retract start. Neuron 1 displays a pause in firing aligned to the onset of reach and persisting during movement execution. Neuron 2 increases in firing at reach start and pauses for execution of forelimb retraction. Note the reliability across multiple trials of the same movements as seen in single-trial raster plots.
