Extended Data Fig. 1: Location and modulation of recorded SNr neurons.
From: Dynamic basal ganglia output signals license and suppress forelimb movements
a, Allen Common Coordinate Framework (CCF) location of recorded SNr single units with baseline firing rate greater than 5 Hz. Sections are spaced 100 micrometres (CCF levels). Top is dorsal and right is lateral. b, Schematic of viral injection for retrograde labelling of latRM-projection neurons in SNr (G-deleted Rabies expressing a fluorescent protein localized to the nucleus (nTag)) (left). Location of retrogradely labelled nuclei (from n = 4 mice) in an anteroposterior projection of the SNr (centre) and in single CCF levels (right). Lines represent isodensity lines computed using kernel density estimation. Top is dorsal and right is lateral. c, Single trial raster plots (top) and average firing rate with standard error of the mean (bottom) of SNr neurons aligned to reach start (these are additional examples to the two units shown in Fig. 1). Neuron 3 displays a pause in firing during reaching. Neuron 4 increases in firing around reach start. Neuron 5 displays both an increase (during reach) and a pause (during retract). Note the diverse activity patterns in different single units.
