Fig. 4: Structure-guided hypotheses for homo-oligomeric RNAs.
From: Naturally ornate RNA-only complexes revealed by cryo-EM
a, OLE dimer displayed with AlphaFold 347 models of OapC, OapA dimer and RpsU proteins at their proposed binding sites. b,c, The two half-shells of the RNA nanocages are held together by only a few interactions and hence could open up to encapsulate other biomolecules, such as protein, metabolites, nucleic acids or RNA–protein complexes. b, The RNA nanocage formed by ROOL is shown encapsulating a ribosomal large subunit. c, The RNA nanocage formed by GOLLD is shown exposing the covalently linked tRNAs when open. The sharpened cryo-EM maps are displayed at the following contours 7σ (a), 6σ (b) and 12σ (c).
