Extended Data Fig. 5: Comparison of XLF-XRCC4 interface in crystal structures and NHEJ complexes.
From: Dynamic assemblies and coordinated reactions of non-homologous end joining
a. Superposition of three crystal structures of XLF-XRCC4 complexes (PDB: 3SR2, 3RWR and 3Q4F) colored teal, pink and gray) with an XLR head domain in the ligation complex (olive). The different positions of the interacting XRCC4 head domain among crystal structures are obvious, and 3Q4F (gray) is most similar to the XRCC4 in the ligation complex (blue). b. Superposition of the four XLF-XRCC4 interfaces among ligation and gap-filling complexes. The supportive and active side of the two complexes are nearly the same. The changes between the two sides of NHEJ complexes are smaller than the differences among the crystal structures of XLF-XRCC4.
