Extended Data Fig. 8: DNA is bent at the protein interface of Ku70.
From: Dynamic assemblies and coordinated reactions of non-homologous end joining
a. DNA-PK complexed with Artemis and hairpin DNA (PDB: 7SGL). A black arrow marks where DNA is bent. b-c. NHEJ complex (this study) in two views. The catalytic domain of LIG4 (green) encircles two DNA ends. DNA is bent near the interface between Ku70 and LIG4 (DBD). d-e. DNA is always bent at the interface between Ku70 and DNA-PK, either in the presence of P-KBM (PDB:8EZA) (d) or absence of PAXX (PDB: 7K0Y) (e).
