Extended Data Fig. 4: Systematic comparisons of PTSD versus MDD.
From: Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
a, Binary plot of 1,918 MDD snDEGs indicating occurrence of DEG across cell types. b, Correlation of snRNA-seq average MAST log2FC values to bulk RNA log2FC values (r = 0.72) for MDD snDEGs. c, Heatmap of MAST log2FC values of the top MDD snDEGs per cell type (top) and corresponding values from bulk RNA-seq (bottom). d, Overlap between PTSD snDEGs and snMDD DEGs across cell types. e, RRHO p-value heatmaps showing high enrichment in concordant quadrants and lack of enrichment in discordant quadrants between PTSD and MDD. f, RRHO odds ratio heatmaps showing high enrichment in concordant quadrants and minimal enrichment in discordant quadrants between PTSD and MDD. g, Overlap among PTSD, PTSD (+MDD), and PTSD (-MDD) vs CON up- and down-regulated DEGs across cell types.
