Extended Data Fig. 3: Ku degradation induces IFN signaling.
From: Ku limits RNA-induced innate immunity to allow Alu expansion in primates
a and b, The gene set enrichment analyses (GSEA) for the interferon (a) and NF-kB (b)-pathways at 4 days after Ku degradation in cycling cells. c, The GSEA for the IFN pathway at 24 hr after Ku deletion in cycling cells. d, Pathway analyses of significantly downregulated genes upon Ku-degradation (24 hr). The p-values were calculated using the GOenrich function from the clusterProfiler package in R, with a list of downregulated genes as the input.
