Fig. 1: Recognition of TTYH2 by synthetic nanobodies.
From: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
a, Cryo-EM density (3.7 Å, left) and ribbon representation (right) of the TTYH2–Sb1 complex. b, Cryo-EM density (4.3 Å) of the TTYH2–Sb2 complex. c, Cryo-EM density (8.2 Å) of the TTYH2–Sb1 complex in native vesicles isolated from HEK293 cells overexpressing TTYH2 by binding to resin containing immobilized Sb1. The relationship between views is indicated. The density of the mobile C terminus is in orange. In a–c, TTYH2 subunits are in cyan and magenta, sybodies are in green.
