Fig. 6: Proposed cellular role of TTYH2–APOE interactions.
From: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
Schematic of the processes that lead to the encounter of TTYH2 and APOE-containing lipoprotein particles in endosomes after their receptor-mediated endocytosis and dissociation from the low-density lipoprotein (LDL) receptor after acidification of the endosomal lumen. The interaction of both proteins facilitates the exchange of lipids between the lipoprotein and the endosomal membrane, as illustrated by the magnified diagram of the shaded area (left). The diagram was created using BioRender (https://www.biorender.com).
