Extended Data Fig. 6: Validation of TRPC6 expression in experimental diabetic kidney disease.
From: Pathology-oriented multiplexing enables integrative disease mapping
(a) Expression of TRPC6 in normal murine proximal tubuli using immunogold in electron microscopy. This is a representative image from 3 biological replicates. (b) Expression of TRCP6 using Imaging Mass Cytometry in the human kidney (controls and diabetic kidney disease; DKD). These are representative images from 2 biological replicates per condition. (c) Schematic representation of a murine model of obesity and early DKD, showing albuminuria at 24 weeks of age. (d) Increased expression (distributional shift in pixel intensity) of TRPC6 in proximal tubuli in ob/ob mice at 24 weeks of age. Scale bar in (a) represents 250 nm and scale bars in (b) represent 50 µm. Parts of panel c were created using BioRender (https://biorender.com).
