Extended Data Fig. 10: Laminar distribution and gene expression gradients of MGE GABAergic neurons in cortex and hippocampal formation.
From: Transcriptomic and spatial organization of telencephalic GABAergic neurons
(a) Heatmap showing the proportion of cells in each layer or region of the isocortex and HPF for supertypes in the 52 Pvalb Gaba and 53 Sst Gaba subclasses. (b,c) Representative MERFISH sections showing the distribution of neurons across isocortex and HPF in select supertypes from subclasses 52 Pvalb Gaba (b) and 53 Sst Gaba (c). (d,e) Dot plots showing expression level of genes driving the gene expression gradient along the cortical depth for supertypes (ordered from deep to superficial) within the 52 Pvalb Gaba (d) and 53 Sst Gaba (e) subclasses. Dot size and colour indicate proportion of expressing cells and average expression level in each supertype, respectively. Genes labelled in green are shared between the two subclasses. (f, g) Representative examples of genes that drive the laminar gene expression gradient, plotted on the same MERFISH section as in panels b and c, shown for the 52 Pvalb Gaba (f) and 53 Sst Gaba (g) subclasses. Each cell is coloured by relative gene expression level. Triangular schematic denotes the most granular hierarchical level shown in the panels (ST: supertype).
