Fig. 1: UKB pain intensity (most bothersome) GWAS identifies novel signals.
From: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
a, The frequency distribution of pain intensity scores among participants, measured using the numerical rating scale. Pain scores range from 0 (no pain) to 10 (worst possible pain). QC, quality control. b, In a Manhattan plot from the UKB pain intensity GWAS (n = 132,552 participants), the genome-wide significant threshold is demarcated by a horizontal red line at −log10-transformed unadjusted P = 5 × 10−8, obtained by linear regression testing for the association of the residualized phenotype and genetic markers using two-step Regenie. c, A regional plot centred on rs10625280, the principal SNV within the SLC45A4 gene, elucidates associations within this genomic region in the UKB pain intensity GWAS (n = 132,552). SNVs are differentiated by a colour gradient on the basis of their linkage disequilibrium (r2 values) with the top independent significant SNV. The top lead SNVs in genomic risk loci, lead SNVs and independent significant SNVs are distinctly marked—encircled in black and highlighted in dark purple, purple and red, respectively. SNPs, single-nucleotide polymorphisms.
