Extended Data Fig. 4: Sensory features encoded by the SPFp.
From: A circuit that integrates drive state and social contact to gate mating
a, Schematic of experimental paradigm. b-c, Mean firing rate for each SPFp integration cell (b) and the population (c) in response to a ball or anesthetized conspecifics (n = 49 cells, 3 mice; 10 trials per condition). d, Same as in c, but for a ball painted with female urine to provide pheromonal odors. e, Mean activity of SPFp cells to various object contact conditions by the robotic arm. f, Mean activity to object contact over time of transient (top; n = 35 cells) and sustained (bottom; n = 50 cells) SPFp face-responsive cells. Bin size; 2 s. g, Mean activity of face-responsive SPFp cells to touch to one whisker (most preferred for each cell), multiple whiskers or entire contra face (n = 81 cells; 3 mice). h, Mean activity of face-responsive SPFp cells to object contact under whiskers cuts and face numb conditions (n = 71 cells; 3 mice). i, Schematic of recording strategy. j, Normalized mean firing rate of all SPFp cells to face touch and SpVVglut2→SPFp stimulation (n = 94 cells; 4 mice; 10 trials per condition). k, Percent of SPFp cells activated by SpVVglut2→SPFp stimulation relative to baseline (> 2σ; choice probability >0.7 contra selective or <0.3 ipsi selective). l, Representative image of limb motion tracking (arbitrary units, top) and percent of limb movements (bottom) located ipsilateral, in front, and contralateral relative to the SPFp during SpVVglut2→SPFp stimulation. m, Mean activity of SPFp cells (top) and peak latency (bottom) aligned to SpVVglut2→SPFp stimulation (blue) or limb movement onset (grey; n = 94 cells). Dots represent individual cells. *p < 0.05, ***p < 0.001; ns, not significant. For all figure panels, data are mean ± SEM. See Table S2 for further details of the statistical analyses.
