Extended Data Fig. 7: Genotype-phenotype driver mutation map.
From: Fluctuating DNA methylation tracks cancer evolution at clinical scale
Inferred growth rate (a) and effective population size (b) of individual CLL samples separated by driver mutational status for common driver alterations (mutations in TP53, SF3B1, NOTCH1, ATM, POT1 and IGLV3-21R110, and copy number alterations (CNAs) in del(11q22.3), del(13q14.3), del(17p13.1) and trisomy12). Differences between genotypes were tested using Mann-Whitney U tests and Benjamini-Hochberg FDR corrected. Tests were performed on U-CLL and M-CLL patients separately to remove differences solely due to with IGHV status.
