Extended Data Fig. 3: Orthogonal cytokine receptor signalling enhances antitumor efficacy of pmel T cells in B16F10 tumour model without causing toxicity.
From: Expanding the cytokine receptor alphabet reprograms T cells into diverse states
a,b, Experimental setting is described in Fig. 2a. Relative body weight of mice post indicated treatment. c, Experimental setting is described in Fig. 2a. Shown are individual tumour growth curves. Indicated are numbers of tumour-free mice among the total number of mice in the group. d, Experimental setting is described in Fig. 2a (n = 5 animals). e, WT mouse T cells transduced with the indicated orthogonal chimeric receptor were cultured in MSA-oIL2 (100 nM) for two days (n = 4 biologically independent samples). Shown are viable T cell counts. Shown are average tumour growth curves. All data represent mean ± s.e.m. and are analysed by one-way (e) or two-way ANOVA with Tukey’s post-test (d).
