Extended Data Fig. 9: Influence of LHb coca-5HT3 expression on cocaine-induced dopamine levels in NAc.
From: Cocaine chemogenetics blunts drug-seeking by synthetic physiology
a-d, Time course (z-score) of GRABDA response in control rats treated with saline or cocaine (a, c) (10 mg/kg: two-way RM ANOVA; treatment main effect (F(1, 5) = 32.2, p = 0.002), time main effect (F(2.6, 13.1) = 4.56, p = 0.2), treatment × time interaction (F(1.7, 8.8) = 21.45, p = 0.005, 20 mg/kg: two-way RM ANOVA; treatment main effect (F(1, 5) = 13.61, p = 0.014), time main effect (F(1.4, 7.1) = 2.3, p = 0.17), treatment × time interaction (F(1.4, 7.2) = 5.09, p = 0.04) and coca-5HT3 rats treated with saline or cocaine (b, d) (10 mg/kg: two-way RM ANOVA; treatment main effect (F(1, 4) = 5.05, p = 0.08), time main effect (F(1.4, 5.6) = 1.12, p = 0.36), treatment × time interaction (F(1.1, 8.8) = 1.24, p = 0.33, 20 mg/kg: two-way RM ANOVA; treatment main effect (F(1, 4) = 0.41, p = 0.55), time main effect (F(2.4, 9.7) = 0.52, p = 0.63), treatment × time interaction (F(1.3, 5.4) = 0.37, p = 0.63). GRABDA response in the medial nucleus accumbens shell measured using fibre photometry in rats with coca-5HT3 in the LHb (n = 5 rats) and in controls (n = 6 rats). Data is shown as mean ± sem.
