Extended Data Fig. 12: Combination treatment with chemotherapy and anti-glutamatergc drugs.
From: Functional synapses between neurons and small cell lung cancer
a-f) Representative MRI scans of tumor-bearing Rb1fl/fl;Trp53fl/fl mice under different treatments. Tumors are pseudocolored in red. a, b) Mouse treated with etoposide and cisplatin (EC), showing the increase in tumor size after two months. c, d) Mouse treated with EC and DCPG (ECD), showing the increase in tumor size after two months. e, f) Mouse treated with EC and riluzole (ECR), showing a stable disease after two months. g) Median tumor burden for RP mice treated with EC (n = 11), ECR (n = 13) or ECD (n = 10). q-values: two-sided Mann-Whitney test with FDR correction. h) Waterfall chart, showing the best response of individual tumors, grouped by mouse. The mice are sorted based on the total best response. i) Time required for tumors to reach a size five fold greater than the size at inclusion for mice treated with EC (n = 9), ECD (n = 9) or ECR (n = 10). q-values: two-sided Mann-Whitney test with FDR correction. j) Best response achieved throughout treatment, calculated based on the total tumor burden for each mouse for mice treated with EC (n = 10), ECR (n = 9) and ECD (n = 10). q-values: two-sided Mann-Whitney test with FDR correction.
