Fig. 3: Membrane-embedded regions.

a, Side views of the MPR forming hydrophobic interactions and hydrogen bonds with fusion loop I of DI. b, Top view of the MPR helices with residues forming the hydrophobic cleft marked in pink and the serine spine in black dashed lines. Hydrophobicity is shown in half-transparent surface rendering. For clarity, DI is not shown. c, Bottom view of fusion loop I with residues forming the hydrophobic footprint and hydrophobic surface. Structures are shown in ribbon rendering and selected residues are marked in three-letter code and shown in sticks with atoms shown in blue for nitrogen, red for oxygen and yellow for sulfur. The MPR is not shown to allow the hydrophobic footprint of fusion loop I to be seen clearly. Hydrophobicity is shown ranging from dark cyan (most hydrophilic) to white to gold (most lipophilic).