Fig. 5: HSV-2 gB bound by Nb1_gbHSV.
From: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
a, Linear diagram of the domain architecture of HSV-2 gB as in Fig. 2. Regions not resolved in the structure are marked with dashed lines in brown for postfusion on top and in violet for prefusion gB below. b, Postfusion structure of HSV-2 gB in ribbon style rendering, overlaid with the semi-transparent electron microscopy density (contour level 0.0825). Domains are marked by Roman numerals. Location of the membrane is indicated by a dashed line. Modelled glycosylations are shown in white. Atoms in residues shown in stick style with blue for nitrogen, red for oxygen and yellow for sulfur. c, Prefusion structure of HSV-2 gB shown as in b with insets showing detailed views of structural features. d, Regions that were mutationally stabilized are shown. Transparent overlays show the stabilized HSV-1 gB structure in comparison with wild-type HSV-2 gB.
