Extended Data Fig. 4: Structural differences between HSV-1 and HCMV prefusion gB.
From: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
Full gB structures are shown left and right4 in ribbon style with domains marked by roman numerals and coloured as in3. Transmembrane domain (TMD) and MPR are coloured as in3. Secondary structure elements are numbered for HSV-1 gB as in3 and HCMV gB as in4. Region and viewing angle of the other panels are indicated by dashed boxes. (1)-(3) Detailed views of the structural features within domains with the HSV-1 gB structure shown in left and HCMV structure (PDB: 7KDP)4 shown in right boxes indicated by the structural pictograms at the top. The HCMV specific inhibitor WAY-174865 (WAY) is marked in orange. Selected residues are marked in three-letter code and shown in sticks with atoms shown in blue for nitrogen, red for oxygen and yellow for sulphur.
