Extended Data Fig. 5: Spatial mapping of DNA methylation and RNA expression in the brain and spinal cord region of E11 mouse embryo.
From: Spatial joint profiling of DNA methylome and transcriptome in tissues
a, Heatmaps illustrating the spatial distribution of DNA methylation levels (top rows) and RNA expression levels (bottom rows) for marker genomic loci and corresponding genes in the brain and spinal cord regions (W2) of E11 mouse embryo. b, GO enrichment analysis from one-sided hypergeometric test for differentially expressed genes in clusters W2. The dot plots show the top GO terms for biological processes enriched in each cluster. The x-axis represents the GeneRatio, and the y-axis lists the GO terms. The size of the dots indicates the count of genes associated with each term, and the color represents the adjusted p-value (p.adjust). c, In situ hybridization (ISH) images from the Allen Developing Mouse Brain Atlas55 show the spatial distribution of markers of oligodendrocyte progenitors and premature oligodendrocytes in the E11 mouse embryo. The images display the expression patterns of markers Olig2 and Nkx2-1 for oligodendrocyte progenitors, and Emx1 and Cdon for premature oligodendrocytes. These ISH images highlight the regions where these progenitor and premature cells are localized within the tissue.
