Extended Data Fig. 6: Spatial mapping of DNA methylation and RNA expression in the craniofacial region of E11 mouse embryo.
From: Spatial joint profiling of DNA methylome and transcriptome in tissues
a, Heatmap of DNA methylation levels for the top 10 differentially methylated genomic loci in the craniofacial region (cluster W0) of E11 mouse embryo. Each row represents a specific genomic locus, and each column represents a different cluster. The color scale indicates the Z-scores of DNA methylation levels. b, Heatmap of expression levels for nearby genes corresponding to the genomic loci in a. Each row represents a specific gene, and each column represents a different cluster. The color scale indicates the Z-scores of gene expression levels. c, Spatial mapping of DNA methylation and RNA expression levels for selected marker genes in the craniofacial region (W0) of E11 mouse embryo. d, GO enrichment analysis from one-sided hypergeometric test for differentially expressed genes in clusters W0. The dot plots show the top GO terms for biological processes enriched in each cluster. The x-axis represents the GeneRatio, and the y-axis lists the GO terms. The size of the dots indicates the count of genes associated with each term, and the color represents the adjusted p-value (p.adjust).
