Extended Data Fig. 6: Adipose-specific ACOX2 overexpression enhances thermogenesis and metabolic health.
From: Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
a, Media glycerol levels of fresh BAT explants from ACOX2Adipo-OE (N = 5) or WT (N = 4) mice incubated in media containing vehicle or isoproterenol for 2 h. b, Core body temperature prior to and after cold exposure in ACOX2Adipo-OE and WT mice treated with 25 mg/kg BCAT-IN-2 or vehicle for 1 week. N = 7. c, Food intake of ACOX2Adipo-OE and WT mice. N = 7. d, Fecal FFA content of ACOX2Adipo-OE and WT mice. N = 6. e, Locomotor activity of ACOX2Adipo-OE and WT mice. N = 6. f, Body weight of HFD-fed ACOX2Adipo-OE and WT male mice. N = 8. g, Body composition analysis in HFD-fed ACOX2Adipo-OE and WT male mice. N = 8. h, GTT analysis in HFD-fed ACOX2Adipo-OE and WT male mice. N = 8. i, ITT analysis in HFD-fed ACOX2Adipo-OE and WT male mice. N = 8. Data are reported as mean ± SEM and are from biologically-independent samples. One-way ANOVA with Fisher’s LSD in a and b and two-way ANOVA with Fisher’s LSD in f, h, and i; Two-sided unpaired Student’s t test in g.
