Extended Data Fig. 5: Microglia comparison with Sun et al. dataset. | Nature

Extended Data Fig. 5: Microglia comparison with Sun et al. dataset.

From: Repeated head trauma causes neuron loss and inflammation in young athletes

Extended Data Fig. 5: Microglia comparison with Sun et al. dataset.

a. UMAP depicting microglia from Sun et al. dataset with original labels. b. Microglia from Butler et al. dataset projected onto Sun dataset UMAP space with original labels. n = 28 individuals. c. Microglia from Butler et al. dataset projected onto Sun dataset UMAP space with predicted Sun labels. n = 28 individuals. d. Bar plot depicting result of boostrapping, with number of predicted microglial labels and error bars depicting bootstrap confidence. e. UMAP depicting Butler microglia projected onto Sun dataset UMAP space colored by label consistency throughout bootstrapping. f. Stacked barplot depicting proportion of Butler microglia with Sun dataset labels across pathological groups. g. Stacked barplot depicting proportion of predicted labels across original labels within Butler dataset microglia showing fidelity across original labels and predicted labels.

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