Extended Data Fig. 2: Cell type proportions, OPCs, Oligodendrocytes, and T-Cells.

a. Bar plots of overall cell type proportions across pathological groups with each dot representing a sample, bars represent the mean, error bars represent standard error of the mean. Statistical analysis performed by ANOVA with Bonferroni correction. Test was two-tailed. n = 28 individuals. b. UMAP depicting OPCs colored by Seurat clustering, solid arrow indicating RHI/CTE depleted cluster. c. Stacked bar plot showing OPC Seurat cluster distribution across pathological groups. d. Bar plots showing OPC cluster distribution across control and pathological group or control and RHI-exposed samples, bar represents mean, error bars show standard error of the mean. Statistical analysis performed by ANOVA with Bonferroni correction (left) and two-tailed Mann-Whitney U test. n = 28 individuals. e. Heatmap showing GO analysis of OPC cluster DEGs. Statistics generated with GSEA and single-tailed hypergeometric test with Benjamini-Hochberg multiple hypothesis correction. f. UMAP showing oligodendrocytes colored by Seurat cluster, solid arrow indicates RHI and CTE depleted cluster. g. Stacked bar plot showing oligodendrocyte pathological group distribution per Seurat cluster. h. Bar plots representing cluster distribution across pathological groups or control and RHI-exposed samples. Bar represents mean, error bar represents standard error of the mean. Statistical analysis performed by ANOVA with Bonferroni correction (left) or two-tailed t-test (right). n = 28 individuals. i. Heatmap showing GO analysis of oligodendrocyte cluster DEGs. Statistics generated with GSEA and single-tailed hypergeometric test with Benjamini-Hochberg multiple hypothesis correction. j. UMAP showing T cells colored by Seurat cluster. k. Heatmap of GO analysis of T cell cluster DEGs. Statistics generated with GSEA and single-tailed hypergeometric test with Benjamini-Hochberg multiple hypothesis correction.