Extended Data Fig. 2: MPCA edges recapitulate metabolite-transporter relationships.
From: Covariation MS uncovers a protein that controls cysteine catabolism
(a) Metabolite-transporter relationship as a form of metabolite-protein co-regulation. (b) MPCA edges recapitulate 26% of all protein-metabolite edges in the transporter classification database (TCDB) involving molecules measured in MPCA. (c) Visualization of TCDB transporter-metabolite relationships recapitulated by MPCA edges. (d) Examples of TCDB transporter-metabolite relationships recapitulated by MPCA edges. (e) Pairwise correlations between glucose and HK1, HK2, HK3, SLC2A1, SLC2A3, and SLC2A4. (f) Pairwise correlations between ornithine and OAT, OTC, SLC22A15, and SLC7A2. (g) Shared and unique protein-metabolite edges in BAT and liver. (h) The average number of TCDB transporters each metabolite has. All- all metabolites; TCDB mapped- metabolites that have their TCDB transporters mapped in MPCA; TCDB-unmapped- metabolites that did not have their TCDB transporters mapped in MPCA.
