Extended Data Fig. 3: Loss of MGME1 elicits cGAS-STING-dependent innate immune signalling.
From: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
a, b, ISG expression in Mgme1+/+ and Mgme1−/− immortalized MEFs treated with the indicated esiRNA for 72 h. n = 3 biologically independent experiments. c, ISG expression in Mgme1+/+ and Mgme1−/− immortalized MEFs treated with the TBK1 inhibitor BX795 (0.5 μM) for 72 h. n = 3 biologically independent experiments. d, e, ISG expression in Mgme1+/+ and Mgme1−/− immortalized MEFs treated with the indicated siRNA for 72 h and measured by RT-qPCR. n = 3 biologically independent experiments. P values were calculated using two-way analysis of variance (ANOVA) with Tukey’s multiple comparisons test (a, b, c, d, e). Data are presented as mean ± SD.
