Fig. 2: Heritability of age at autism diagnosis.
From: Polygenic and developmental profiles of autism differ by age at diagnosis
a, SNP-based heritability (h2) for age at autism diagnosis in the SPARK cohorts, calculated using single-component genome-wide complex trait analysis with a genomic-relatedness-based restricted maximum-likelihood approach (GCTA-GREML) for the SPARK Discovery cohort (orange dashed line, n = 16,786), SPARK Replication cohort (purple dashed line, n = 8,558) and a meta-analysis of the two (light blue solid line, n = 25,344), and iPSYCH, calculated using linkage disequilibrium score regression coefficient (LDSC) (solid green line, n = 18,965). b, SNP-based heritability (GCTA-GREML) in the SPARK cohorts after accounting for various clinical and sociodemographic factors. A ‘+’ indicates the baseline model in addition to the specified covariates. The x axis has been truncated at 0 and 0.25. In a and b, central points represent SNP-based heritability estimates and error bars indicate 95% confidence intervals. Sample sizes for b are provided in Supplementary Table 10. PC, genetic principal component; RBS-R, Repetitive Behavior Scale-Revised; SCQ, Social Communication Questionnaire; SES, socioeconomic status.
