Fig. 2: A ProArg-free diet enhances tumour growth suppression by DFMO in MYCN-driven neuroblastoma.
From: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
a, Schematic of two-factor intervention, including the ProArg-free diet (from day 21) and DFMO treatment via the drinking water (1%, from day 0 to nursing mothers and directly to pups from day 28) in the Th-MYCN genetically modified mouse model. b, Kaplan–Meier curve of tumour-free survival with combined CD or ProArg-free diet plus DFMO. P value from log-rank test compared to CD. c, Tumour growth, defined as tumour mass at death normalized by day of life. Two-tailed t-test compared to CD. Data are mean ± s.e.m. CD: n = 13; CD + DFMO: n = 14; ProArg-free: n = 13; ProArg-free + DFMO: n = 14. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Panel a created in BioRender. Morscher, R. (2025) https://BioRender.com/n9dgse0.
