Fig. 6: Modulation of interstasis by CLK kinases.
From: Collective homeostasis of condensation-prone proteins via their mRNAs
a, TRA2B and SC35 immunofluorescence in cells treated either with DMSO or 1 µM CLK-IN-T3 for 8 h. b, Example image of SON immunofluorescence and EIF3A HCR-FISH in cells treated either with DMSO or 1 µM CLK-IN-T3 for 16 h. c, The nuclear–cytoplasmic distribution of reporter transcripts binned by their total GeRM scores. Data from cells treated either with DMSO or 1 µM CLK-IN-T3 for 2 h before the induction of the reporter transcript pool for 6 h. The right panel shows the group means per sample. d, Schematic detailing the interstasis of proteins with charged low-complexity domains. All statistical comparisons were performed using a Welch t-test with FDR correction for multiple testing, where *P < 0.05 and **P < 0.01. Precise P values can be found in the Source Data. The black dashed line represents no change between conditions.
