Extended Data Fig. 3: Codon biases within R-LCDs across species.
From: Collective homeostasis of condensation-prone proteins via their mRNAs
a, Principal component analysis of the arginine codon usage within LCDs containing at least 20% arginine (R-LCDs). R-LCDs are categorised into three groups of equal size using the first principal component. b, The codon usage of the groups of R-LCDs defined in panel a. c, The representation of amino acids within the groups of R-LCDs defined in panel a. d-e, The codon usage of R-LCDs from genes with either ‘nuclear speck’ or ‘RNA binding’ gene ontology terms compared to R-LCDs without those annotations. f, The proportion of charged amino acids within the R-LCD categories defined in panel a. g, The percentage of proteins containing at least one R-LCD in different species. h, the percentage of LCDs that contain at least 20% arginine in different species. i, the Spearman’s rank correlations of codon usage within R-LCDs in different species. Pairwise significance testing are FDR-corrected Welch t-tests, where * = p < 0.05, ** = p < 0.01, *** = p < 0.001. Precise p-values are found in Source Data.
