Extended Data Fig. 8: ZNF729 binds transposable elements in hnPSCs.
From: A human-specific regulatory mechanism revealed in a pre-implantation model
a. ZNF729 is the most dysregulated KZFP in the blastoids epiblast upon LTR5Hs-repression. Scatter plot depicting expression changes in KZFPs (curated in Krabopedia99) in the blastoids epiblast upon LTR5Hs repression (x-axis) vs their expression in hnPSCs (y-axis). FDR 5%. b. Histogram representing overrepresented classes of transposable elements (TEs) in the ZNF729-FH bound DNA regions. Only the top 12 families are represented. Y-axis displays the number of bound TEs from each family. c. IGV genome browser capture of ZNF729-FH ChIP-seq signal (top two tracks, purple) or TRIM28 ChIP-seq signal (bottom two tracks, turquoise) in DMSO treated (control) and 24 h dTAGv-1 treated ZNF729-FH at loci containing TEs bound by ZNF729 (SVA_C, left panel, hg38 chr3:41,980,857-41,986,113; LTR12C, right panel hg38 chr2:38,395,456-38,401,019).
