Extended Data Fig. 7: Power analysis of paternal transmission.
From: Hotspots of human mutation point to clonal expansions in spermatogonia
Statistical power (i.e., the probability of correctly detecting a signal when it exists calculated as the complement of type-2 error rate ß) of the Binomial test for paternal overtransmission relative to the baseline of 0.75 is shown across the range of CES-related mutation rate inflations κ and counts of observed variants. Results are presented for three significance levels: 0.05, 0.01, and 0.001.
