Fig. 1: Immunophenotyping shows alterations in the T helper cell subsets associated with ALS.
From: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis
a–c, Broad representation of lymphocyte subsets (a) and CD4 (b) or CD8 (c) memory T cell subsets in individuals with ALS (n = 19) and in healthy control (HC) donors (n = 20). NKT, natural killer T cell. d, Composition of functional T helper cell subsets defined on the basis of expression of the CCR6, CXCR3 and CCR4 subset markers, in the same donors as in a–c. P values from two-tailed Mann–Whitney tests and geometric mean ± 95% confidence intervals are shown. Fold change (FC) values represent the ratio of geometric values in the ALS–HC cohorts.
