Fig. 3: Mapping specific C9orf72 epitopes from responding individuals with ALS.
From: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis
a, Distribution of recognized epitopes among the 100 peptides spanning the C9orf72 protein sequence, identified in 28 participants with ALS. b, Number of epitopes recognized by each patient with ALS (n = 28) (median of 3, range 0–26). Median and range are shown. c, Number of predicted binding events to the 27 most common HLA II allelic variants, by peptides recognized in three or more patients (n = 21), one or two patients (n = 51) or no patients (n = 23). Binding was predicted using the NetMHCIIpan 4.1 EL prediction method, using a cut-off for a binding event as a predicted binding percentile score threshold of 20% or less26. P value from two-tailed Mann–Whitney test and mean ± 95% confidence intervals are shown.
