Extended Data Fig. 2: Donors with ALS have an IL-5-biased T cell response.
From: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis
Proportion of IFNγ (a) and IL-5 (b) releasing T cells among all cytokine-releasing cells in response to C9orf72 in healthy controls (HC; n = 28) and donors with ALS (n = 28). (c) Ratio of the number of cells releasing IFNγ and IL-5. Total (d), IFNγ- (e), IL-5- (f), and IL-10-mediated (g) T cell responses towards C9orf72 in ALS, HC, Parkinson’s disease (PD; n = 15), and Alzheimer’s disease (AD; n = 15) cohorts (ALS (n = 28) and HC (n = 28) are the same as in Fig. 2 and panels a–c). Proportion of IFNγ- (h) and IL-5-releasing (i) T cells among all cytokine-releasing cells, and ratio of the number of cells releasing IFNγ and IL-5 (j), in response to C9orf72 in HC, ALS, AD, and PD cohorts. P-values from two-tailed Mann–Whitney tests from comparisons of two groups, and from Kruskal-Wallis tests followed by Dunn’s multiple comparisons test for comparison of four groups. Only significant p-values are shown, the complete list of p-values can be found in the Source Data file. Geometric mean ± 95% confidence interval is shown. Fold change (FC) values represent the ratio of geometric values in ALS/HC.
