Extended Data Fig. 7: Differential expression analysis of micronucleated cells.
From: Origins of chromosome instability unveiled by coupled imaging and genomics
(a) Volcano plots of differentially-expressed genes identified by coupling the MAGIC platform with single-cell RNA sequencing, contrasting normal vs. micronucleated cells in MCF10A (left panel) and RPE-1 (right panel) wild-type cells. Differentially expressed (DE) genes are in blue if down-regulated or red if up-regulated. (b) Enrichment analysis for Hallmark gene sets from the Human Molecular Signatures Database (MSigDB). Upper panel MCF10A, lower panel RPE-1. (c) Heatmap plot summarizing gene ontology (GO) enrichment for MCF10A (left panel) and RPE-1 (right panel). Redundant GO terms were clustered by semantic similarity, indicated by the blue to red heatmap gradient.
