Extended Data Fig. 12: The neuroprotective PU.1low, lymphoid+/CD28+ microglia subpopulation expands in TIM-3-KO mice (related to Fig. 5). | Nature

Extended Data Fig. 12: The neuroprotective PU.1low, lymphoid+/CD28+ microglia subpopulation expands in TIM-3-KO mice (related to Fig. 5).

From: Lymphoid gene expression supports neuroprotective microglia function

Extended Data Fig. 12: The neuroprotective PU.1low, lymphoid+/CD28+ microglia subpopulation expands in TIM-3-KO mice (related to Fig. 5).The alternative text for this image may have been generated using AI.

(a-d) Single-cell sequencing of human microglia from Kimura et al.49. (a) Uniform manifold approximation and projection (UMAP) visualizations (left). (b, c) Dot plot (b) and feature plots (c) show the expression of Cd28, Spi1, and selected PU.1low microglia expressed lymphoid genes (Cd28, Pdcd1, Cd274, Sox5, Dkk2, Prkcq, Btla) in UMAP visualizations. Marker genes for subsets are shown in Supplementary Table 13. (d) The bar graphs show the change in the percentage of microglia comprising the lymphoid + /Cd28+ populations (cluster 14) in 5xFAD (1%) and 5xFAD, TIM-3-KO mice (3%).

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